Karel Pacak Selected Research

Precision Medicine

1/2024	Imaging of Pheochromocytomas and Paragangliomas.
1/2023	Nuclear medicine in pheochromocytoma and paraganglioma: at a crossroads with precision medicine.
10/2022	Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment.
10/2021	Deep Membrane Proteome Profiling Reveals Overexpression of Prostate-Specific Membrane Antigen (PSMA) in High-Risk Human Paraganglioma and Pheochromocytoma, Suggesting New Theranostic Opportunity.
1/2021	Variants and Pitfalls of PET/CT in Neuroendocrine Tumors.
1/2021	Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World.
1/2020	Molecular Imaging in the Era of Precision Medicine: Paraganglioma as a Template for Understanding Multiple Levels of Analysis.
1/2020	Phosphoprotein-based biomarkers as predictors for cancer therapy.
10/2019	Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine.
10/2019	Current experts' views on precision nuclear medicine imaging of phaeochromocytoma and paraganglioma.

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Karel Pacak Research Topics

Disease

227	Neoplasms (Cancer) 04/2024 - 01/2002
193	Pheochromocytoma 04/2024 - 03/2002
172	Paraganglioma (Paragangliomas) 04/2024 - 03/2002
44	Neoplasm Metastasis (Metastasis) 12/2023 - 08/2006
29	Hypoxia (Hypoxemia) 12/2023 - 09/2012
27	Neuroendocrine Tumors (Neuroendocrine Tumor) 04/2024 - 07/2003
21	Hypertension (High Blood Pressure) 04/2024 - 09/2002
14	Multiple Endocrine Neoplasia Type 2a (MEN 2) 06/2017 - 06/2005
13	von Hippel-Lindau Disease (von Hippel Lindau Disease) 10/2022 - 02/2005
9	Carcinogenesis 01/2019 - 06/2005
8	Tachycardia (Tachyarrhythmias) 12/2023 - 03/2008
8	Polycythemia (Erythrocytosis) 10/2023 - 03/2013
8	Obesity 01/2019 - 11/2006
8	Neurofibromatosis 1 (Neurofibromatosis Type I) 06/2017 - 06/2005
6	Disease Progression 11/2023 - 01/2013
6	Renal Cell Carcinoma (Grawitz Tumor) 01/2023 - 03/2012
6	Heart Failure 12/2022 - 11/2006
5	Somatostatinoma 05/2024 - 03/2013
5	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2023 - 01/2008
5	Cardiomyopathies (Cardiomyopathy) 07/2019 - 06/2011
4	Hypotension (Low Blood Pressure) 12/2023 - 07/2003
4	Hypertensive Crisis 12/2023 - 01/2004
4	Hemangioblastoma 12/2021 - 01/2017
4	Hyperplasia 07/2019 - 05/2006
4	Cushing Syndrome 08/2018 - 05/2004
3	Pain (Aches) 04/2024 - 01/2020
3	Glioblastoma (Glioblastoma Multiforme) 01/2024 - 08/2017
3	Adrenal incidentaloma 01/2024 - 08/2005
3	Neuroblastoma 08/2023 - 03/2005

Drug/Important Bio-Agent (IBA)

98	CatecholaminesIBA 04/2024 - 03/2002
84	Succinate Dehydrogenase (Fumarate Reductase)IBA 04/2024 - 06/2005
29	Norepinephrine (Noradrenaline)FDA LinkGeneric 12/2020 - 02/2002
25	Proteins (Proteins, Gene)FDA Link 09/2023 - 10/2005
23	Biomarkers (Surrogate Marker)IBA 10/2023 - 12/2002
21	Epinephrine (Adrenaline)FDA LinkGeneric 12/2023 - 06/2003
21	EnzymesIBA 09/2023 - 08/2006
18	MetanephrineIBA 01/2023 - 05/2002
17	Radioisotopes (Radionuclides)IBA 11/2023 - 05/2004
16	NormetanephrineIBA 01/2023 - 05/2002
16	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021 - 08/2004
15	RadiopharmaceuticalsIBA 01/2021 - 08/2004
13	Succinic Acid (Succinate)IBA 12/2023 - 01/2013
13	3-methoxytyramine (methoxytyramine)IBA 01/2023 - 04/2005
13	Dopamine (Intropin)FDA LinkGeneric 04/2019 - 07/2003
12	Somatostatin Receptors (Somatostatin Receptor)IBA 04/2024 - 03/2004
12	gallium Ga 68 dotatateIBA 10/2022 - 02/2016
12	fluorodopa F 18IBA 03/2020 - 10/2007
11	LigandsIBA 01/2024 - 03/2005
11	Hormones (Hormone)IBA 01/2022 - 08/2003
11	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2021 - 08/2008
11	3-Iodobenzylguanidine (Iobenguane)IBA 01/2019 - 09/2003
10	MannansIBA 01/2024 - 05/2019
8	Phosphotransferases (Kinase)IBA 11/2022 - 06/2013
8	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 06/2005
8	Erythropoietin FDA Link 01/2021 - 06/2005
7	DNA (Deoxyribonucleic Acid)IBA 05/2024 - 09/2002
7	Adrenergic Receptors (Adrenergic Receptor)IBA 02/2022 - 01/2010
7	Myc associated factor XIBA 01/2018 - 05/2012
7	Messenger RNA (mRNA)IBA 11/2012 - 10/2005
7	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 11/2012 - 02/2003
6	lutetium Lu 177 dotatateIBA 04/2024 - 06/2019
6	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2024 - 05/2019
6	4-carboxyphenylglyoxalIBA 01/2023 - 01/2020
6	Tricarboxylic AcidsIBA 01/2022 - 08/2015
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2021 - 08/2014
6	Peptide Receptors (Peptide Receptor)IBA 01/2021 - 12/2016
6	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2013
5	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2023 - 02/2016
5	Transcription Factors (Transcription Factor)IBA 01/2023 - 08/2006
5	Fumarate Hydratase (Fumarase)IBA 01/2023 - 03/2016
5	Peptides (Polypeptides)IBA 01/2021 - 05/2007
5	Carboxypeptidase H (Carboxypeptidase E)IBA 01/2020 - 11/2010
5	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 04/2012
4	VaccinesIBA 01/2024 - 09/2020
4	Everolimus FDA Link 01/2024 - 05/2015
4	Temozolomide (Temodar)FDA LinkGeneric 11/2023 - 01/2017
4	endothelial PAS domain-containing protein 1IBA 10/2023 - 05/2013
4	RNA (Ribonucleic Acid)IBA 10/2022 - 12/2018
4	Retinaldehyde (Retinal)IBA 12/2021 - 11/2017
4	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2021 - 01/2010
4	IronIBA 01/2021 - 03/2011
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2021 - 06/2013
4	Oxygen (Dioxygen)IBA 01/2020 - 03/2013
4	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 04/2019 - 12/2008
4	FumaratesIBA 01/2019 - 01/2014
4	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2018 - 01/2010
4	ParaffinIBA 01/2017 - 03/2002
4	Dihydroxyphenylalanine (Dopa)IBA 02/2012 - 08/2004
4	Adrenocorticotropic Hormone (ACTH)FDA Link 08/2005 - 03/2004
3	LipidsIBA 03/2024 - 01/2020
3	AlpelisibIBA 01/2024 - 11/2019
3	Sunitinib (Sutent)FDA Link 11/2023 - 05/2015
3	ProteomeIBA 09/2023 - 06/2019
3	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2023 - 06/2017

Therapy/Procedure

62	Therapeutics 04/2024 - 09/2002
14	Precision Medicine 01/2024 - 11/2016
12	Immunotherapy 02/2024 - 05/2019
11	Drug Therapy (Chemotherapy) 01/2024 - 08/2008
8	Adrenalectomy 01/2020 - 02/2003
7	Radiotherapy 04/2024 - 12/2013